Curves:  Riders must have "low entry speed" in curves--riders can always throttle up after entering the curve.  Entering a curve too hot can find a rider "over the edge" in Colorado.  The bike goes where the eyes go.  Make frequent camera stops and leave your sight-seeing for moments when the kickstand is down.  There is often gravel in curves.

Gravel:  Gravel is on Colorado roads all the time.  Gravel can be deposited by 1) gully washer rains in summer 2) errant automobile motorists slipping off onto the shoulder and spinning gravel up 3) intersecting dirt roads 4) gravel trucks following snow/hail.  Watch for gravel at intersections and curves--it is too late to slow down AFTER entering a curve. 

Weather: Hail, snow, rain can occur any month of the year in Colorado, especially up high.  It is important to have good tread depth on tires in Colorado.  What do you have for your head and eyes with marble size hail falling?  Is it in your saddle bag?  How can you keep yourself and your passenger warm/dry?  Many Colorado cyclists carry an extra-large/extra-strong leaf bag to use as an emergency rain parka or bike cover.

Health is enhanced by 1) good hydration of 10 glasses water/day 2) rest 3) limiting alcohol and caffeine intake.  Sunscreen, lip balm, a humidifier in the room at night, and sunglasses are very helpful.  Avoid heavy meals prior to riding.  Keep water readily available and insure rider/passenger remain hydrated.